Samarium in PDB 7lpz: Crystal Structures and Ribonuclease Activity of the Flavivirus Host Factor ERI3 That Is Involved in Viral Rna Synthesis Define the Eri Subfamily of Structure-Specific 3-Prime - 5-Prime Exoribonucleases

The structure of Crystal Structures and Ribonuclease Activity of the Flavivirus Host Factor ERI3 That Is Involved in Viral Rna Synthesis Define the Eri Subfamily of Structure-Specific 3-Prime - 5-Prime Exoribonucleases, PDB code: 7lpz was solved by R.Thapar, A.S.Andrew, J.A.Tainer, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	37.39 / 1.55
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	58.727, 74.785, 96.879, 90, 90, 90
R / Rfree (%)	15.8 / 19.7

The binding sites of Samarium atom in the Crystal Structures and Ribonuclease Activity of the Flavivirus Host Factor ERI3 That Is Involved in Viral Rna Synthesis Define the Eri Subfamily of Structure-Specific 3-Prime - 5-Prime Exoribonucleases (pdb code 7lpz). This binding sites where shown within 5.0 Angstroms radius around Samarium atom.
In total 4 binding sites of Samarium where determined in the Crystal Structures and Ribonuclease Activity of the Flavivirus Host Factor ERI3 That Is Involved in Viral Rna Synthesis Define the Eri Subfamily of Structure-Specific 3-Prime - 5-Prime Exoribonucleases, PDB code: 7lpz:
Jump to Samarium binding site number: 1; 2; 3; 4;

Samarium binding site 1 out of 4 in the Crystal Structures and Ribonuclease Activity of the Flavivirus Host Factor ERI3 That Is Involved in Viral Rna Synthesis Define the Eri Subfamily of Structure-Specific 3-Prime - 5-Prime Exoribonucleases


Mono view


Stereo pair view

A full contact list of Samarium with other atoms in the Sm binding site number 1 of Crystal Structures and Ribonuclease Activity of the Flavivirus Host Factor ERI3 That Is Involved in Viral Rna Synthesis Define the Eri Subfamily of Structure-Specific 3-Prime - 5-Prime Exoribonucleases within 5.0Å range: probe atom residue distance (Å) B Occ A:Sm502 b:38.6 occ:0.47 O1P A:AMP501 1.8 44.0 1.0 O A:HOH740 2.0 40.8 1.0 SM A:SM503 2.2 44.7 0.3 OD1 A:ASP150 2.4 40.2 1.0 O A:HOH677 2.4 47.8 1.0 OD2 A:ASP150 2.4 39.8 1.0 CG A:ASP150 2.7 39.5 1.0 O A:HOH608 2.7 53.1 1.0 O A:HOH619 2.8 29.8 1.0 P A:AMP501 3.1 41.5 1.0 OD2 A:ASP312 3.4 41.3 1.0 O3P A:AMP501 3.5 42.8 1.0 O A:HOH631 3.8 63.6 1.0 O2P A:AMP501 4.0 44.5 1.0 O5' A:AMP501 4.1 34.9 1.0 CB A:ASP150 4.2 31.3 1.0 CG A:ASP312 4.3 37.5 1.0 O A:HOH634 4.3 29.5 1.0 O A:PHE151 4.4 29.8 1.0 C5' A:AMP501 4.4 32.2 1.0 OE2 A:GLU152 4.5 35.4 1.0 CB A:ASP312 4.5 31.4 1.0 O A:HOH775 4.7 61.1 1.0 OD2 A:ASP249 4.8 34.3 1.0 CA A:ASP150 4.9 28.6 1.0 OD1 A:ASP249 5.0 35.8 1.0

Samarium binding site 2 out of 4 in the Crystal Structures and Ribonuclease Activity of the Flavivirus Host Factor ERI3 That Is Involved in Viral Rna Synthesis Define the Eri Subfamily of Structure-Specific 3-Prime - 5-Prime Exoribonucleases


Mono view


Stereo pair view

A full contact list of Samarium with other atoms in the Sm binding site number 2 of Crystal Structures and Ribonuclease Activity of the Flavivirus Host Factor ERI3 That Is Involved in Viral Rna Synthesis Define the Eri Subfamily of Structure-Specific 3-Prime - 5-Prime Exoribonucleases within 5.0Å range: probe atom residue distance (Å) B Occ A:Sm503 b:44.7 occ:0.26 OD2 A:ASP312 1.9 41.3 1.0 O1P A:AMP501 2.0 44.0 1.0 OD1 A:ASP150 2.1 40.2 1.0 SM A:SM502 2.2 38.6 0.5 OE2 A:GLU152 2.5 35.4 1.0 O2P A:AMP501 2.6 44.5 1.0 P A:AMP501 2.7 41.5 1.0 CG A:ASP312 3.1 37.5 1.0 CG A:ASP150 3.1 39.5 1.0 O A:HOH631 3.2 63.6 1.0 CD A:GLU152 3.5 32.8 1.0 OD2 A:ASP150 3.6 39.8 1.0 O3P A:AMP501 3.6 42.8 1.0 CB A:ASP312 3.8 31.4 1.0 O A:HOH740 3.8 40.8 1.0 O A:PHE151 3.9 29.8 1.0 OE1 A:GLU152 3.9 32.2 1.0 O A:HOH619 3.9 29.8 1.0 O5' A:AMP501 4.0 34.9 1.0 OD1 A:ASP312 4.1 37.3 1.0 CA A:HIS307 4.3 38.5 1.0 O A:HOH608 4.3 53.1 1.0 C5' A:AMP501 4.4 32.2 1.0 CB A:ASP150 4.4 31.3 1.0 O A:HOH677 4.5 47.8 1.0 O A:SER308 4.6 37.7 1.0 C A:HIS307 4.7 37.8 1.0 CA A:GLY309 4.7 32.2 1.0 N A:HIS307 4.8 39.0 1.0 CG A:GLU152 4.8 30.9 1.0 C A:PHE151 4.9 28.8 1.0 C A:SER308 4.9 35.9 1.0 N A:GLY309 5.0 33.0 1.0

Samarium binding site 3 out of 4 in the Crystal Structures and Ribonuclease Activity of the Flavivirus Host Factor ERI3 That Is Involved in Viral Rna Synthesis Define the Eri Subfamily of Structure-Specific 3-Prime - 5-Prime Exoribonucleases


Mono view


Stereo pair view

A full contact list of Samarium with other atoms in the Sm binding site number 3 of Crystal Structures and Ribonuclease Activity of the Flavivirus Host Factor ERI3 That Is Involved in Viral Rna Synthesis Define the Eri Subfamily of Structure-Specific 3-Prime - 5-Prime Exoribonucleases within 5.0Å range: probe atom residue distance (Å) B Occ B:Sm502 b:47.9 occ:0.41 O3P B:AMP501 1.7 44.4 1.0 O B:HOH655 2.0 42.2 1.0 SM B:SM503 2.1 50.2 0.3 OD1 B:ASP150 2.1 44.3 1.0 O B:HOH629 2.7 43.7 1.0 O B:HOH609 2.7 32.2 1.0 OD2 B:ASP150 2.7 42.7 1.0 CG B:ASP150 2.7 39.1 1.0 P B:AMP501 2.9 45.4 1.0 O B:HOH619 2.9 53.9 1.0 O B:HOH603 2.9 51.0 1.0 O1P B:AMP501 3.3 46.8 1.0 OD2 B:ASP312 3.4 40.6 1.0 O2P B:AMP501 3.7 48.5 1.0 O5' B:AMP501 4.0 42.0 1.0 O B:PHE151 4.2 34.0 1.0 CB B:ASP150 4.2 35.2 1.0 C5' B:AMP501 4.3 42.7 1.0 CG B:ASP312 4.4 34.6 1.0 O B:HOH635 4.4 35.9 1.0 OE2 B:GLU152 4.4 37.3 1.0 CB B:ASP312 4.7 29.1 1.0 CA B:ASP150 4.8 32.5 1.0 OD2 B:ASP249 4.8 39.9 1.0 O B:HOH612 4.9 62.6 1.0 C B:ASP150 5.0 34.2 1.0

Samarium binding site 4 out of 4 in the Crystal Structures and Ribonuclease Activity of the Flavivirus Host Factor ERI3 That Is Involved in Viral Rna Synthesis Define the Eri Subfamily of Structure-Specific 3-Prime - 5-Prime Exoribonucleases


Mono view


Stereo pair view

A full contact list of Samarium with other atoms in the Sm binding site number 4 of Crystal Structures and Ribonuclease Activity of the Flavivirus Host Factor ERI3 That Is Involved in Viral Rna Synthesis Define the Eri Subfamily of Structure-Specific 3-Prime - 5-Prime Exoribonucleases within 5.0Å range: probe atom residue distance (Å) B Occ B:Sm503 b:50.2 occ:0.30 SM B:SM502 2.1 47.9 0.4 OD2 B:ASP312 2.1 40.6 1.0 O3P B:AMP501 2.1 44.4 1.0 OD1 B:ASP150 2.2 44.3 1.0 OE2 B:GLU152 2.5 37.3 1.0 O2P B:AMP501 2.6 48.5 1.0 P B:AMP501 2.7 45.4 1.0 O B:HOH603 2.9 51.0 1.0 CG B:ASP150 3.1 39.1 1.0 CG B:ASP312 3.2 34.6 1.0 OD2 B:ASP150 3.5 42.7 1.0 CD B:GLU152 3.5 35.6 1.0 O B:HOH655 3.6 42.2 1.0 O B:PHE151 3.6 34.0 1.0 O1P B:AMP501 3.7 46.8 1.0 O B:HOH609 3.7 32.2 1.0 CB B:ASP312 3.8 29.1 1.0 OE1 B:GLU152 3.9 35.5 1.0 O5' B:AMP501 4.1 42.0 1.0 CB B:ASP150 4.3 35.2 1.0 OD1 B:ASP312 4.3 34.7 1.0 CA B:HIS307 4.4 40.0 1.0 C5' B:AMP501 4.4 42.7 1.0 O B:HOH619 4.5 53.9 1.0 O B:HOH629 4.6 43.7 1.0 C B:PHE151 4.7 34.1 1.0 CA B:GLY309 4.7 30.9 1.0 C B:ASP150 4.8 34.2 1.0 CG B:GLU152 4.8 32.4 1.0 O B:ASP150 4.8 35.9 1.0 C B:HIS307 4.8 38.0 1.0 O B:SER308 4.9 34.2 1.0 N B:HIS307 5.0 36.9 1.0

R.Thapar, A.S.Arvai, J.A.Tainer. Crystal Structures and Ribonuclease Activity of the Flavivirus Host Factor ERI3 That Is Involved in Viral Rna Synthesis Define the Eri Subfamily of Structure-Specific 3' - 5' Exoribonucleases To Be Published.